Effects of Growth Hormone Secretagogues on Prolactin Release in Anesthetized Dwarf (dw/dw) Rats
نویسندگان
چکیده
منابع مشابه
Effects of growth hormone secretagogues on prolactin release in anesthetized dwarf (dw/dw) rats.
In addition to stimulating GH release, GH secretagogues such as GH-releasing peptide-6 (GHRP-6) stimulate small amounts of ACTH and PRL release. Although the effects on ACTH have recently been studied, there is little information about the effects of GHRP-6 on PRL. We have now studied GHRP-6-induced GH and PRL release and their regulation by estrogen (E2) in anesthetized male and female rats an...
متن کاملDevelopment of growth hormone secretagogues.
The GH secretagogues (GHS) were developed by reverse pharmacology. The objective was to develop small molecules with pharmacokinetics suitable for once-daily oral administration that would rejuvenate the GH/IGF-I axis. Neither the receptor nor the ligand that controlled pulse amplitude of hormone release was known; therefore, identification of lead structures was based on function. I reasoned t...
متن کاملGrowth Hormone Secretagogues in Perspective
Introduction The parenteral administration of human growth hormone (HGH) has become an intervention of great significance in anti-aging medicine. There is now frenetic interest in using reliable G H secretagogues i n the form of peptides, such as GHRP-2. Although age-related sarcopenia is related to HGH deficiency, the use of HGH for the building of "lean body mass" has been questioned, especia...
متن کاملGrowth hormone secretagogues exert differential effects on skeletal muscle calcium homeostasis in male rats depending on the peptidyl/nonpeptidyl structure.
The orexigenic and anabolic effects induced by ghrelin and the synthetic GH secretagogues (GHSs) are thought to positively contribute to therapeutic approaches and the adjunct treatment of a number of diseases associated with muscle wasting such as cachexia and sarcopenia. However, many questions about the potential utility and safety of GHSs in both therapy and skeletal muscle function remain ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1998
ISSN: 0013-7227
DOI: 10.1210/en.139.8.3590